The ISG combines the two most common process fabrications, Sterile Access (SA) and GMP, into one assembly with the purge valve integral to the main body, greatly reducing the dead legs of conventional SA and GMP fabrications. By rotating the assembly, one fabricated block body provides three orientations: standard Sterile Access Port (SAP) plus vertical GMP porting above and below the weir, reducing contact surfaces, hold-up volume and dimensional envelope. Standard sizes run 0.5-2 inch (DN15-50). Patent 6,401,756.